Preheat oven to 400 degrees F. Spray a baking sheet with nonstick cooking spray; set aside.
In a mixing bowl or stand mixer, combine self rising flour and Greek yogurt until a thick dough forms. Roll dough out onto a lightly floured surface into a large rectangle (approximately 10”x14”).
In a large mixing bowl, beat together softened cream cheese and Greek yogurt until smooth. Add garlic powder, onion powder, salt, chicken and mushrooms and mix until well combined.
Spread mixture down the center of the dough, leaving 2-3 inches of dough on each side. Use a pizza cutter to cut 1-inch diagonal strips down each side of the dough. Fold 1- inch strips up and over the filling, alternating sides to create a braid.
Brush egg over the top and sides of the loaf, then sprinkle parmesan cheese and fresh parsley on top. Bake for 22-25 minutes, or until golden brown.
Remove from oven, let rest for a few minutes then cut into slices and serve.